Shingles (Herpes zoster) is a nerve and skin infection. Shingles results from activation of chicken-pox virus that has remained in your body since you had chicken-pox perhaps many years ago. The virus activation begins in a nerve root. The rash is usually composed of a red welt with small blisters within this area. It usually itches or is associated with aching in the underlying muscle. Many patients mistakenly believe the lesions are due to spider bites. It's important to seek care immediately since prompt treatment with a prescription antiviral medication can prevent nerve injury and long term pain.